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Conclusion:
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For CD4+ T lymphocytes, we found a significant decrease in the number of naïve, central and effector memory cells and an increased percentage of terminally differentiated cells, regulatory T cells, and of those that were activated or that were expressing PD1 and CD57 markers.
Analyses of patients' CD8+ T cells showed decreased numbers of naïve and central memory and increased amounts of activated cells, accompanied by increased percentages of activated cells and of lymphocytes expressing CD57, PD1, or both.
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Funding:
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Glem Gas SpA (San Cesario, MO, Italy), Sanfelice 1893 Banca Popolare (San Felice S.P., MO, Italy) and Rotary Club Distretto 2072 (Clubs in Modena, Modena L.A. Muratori, Carpi, Sassuolo, Castelvetro di Modena), C.O.F.I.M. SPA & Gianni Gibellini, Franco Appari, Andrea Lucchi, Federica Vagnarelli, Biogas Europa Service & Massimo Faccia, Pierangelo Bertoli Fans Club, Maria Santoro and Valentina Spezzani are strongly acknowledged for their generous support to our research.
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