Conclusion:
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Studies on chemokine receptors and lineage-specifying transcription factors revealed that, among CD4+ T cells, patients displayed a lower percentage of cells expressing CCR6 or CXCR3, and of those co-expressing CCR6 and CD161, but higher percentages of CXCR4+ or CCR4+ cells. No differences were noted in the expression of T-bet or GATA-3.
CD8+ T cells expressed lower percentages of CCR6+, CXCR3+ or T-bet+ cells and of CXCR3+,T-bet+ or CCR6+,CD161+ lymphocytes. We also found higher percentages of cells expressing CCR4+, CXCR4 or GATA-3.
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Funding:
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Glem Gas SpA (San Cesario, MO, Italy), Sanfelice 1893 Banca Popolare (San Felice S.P., MO, Italy) and Rotary Club Distretto 2072 (Clubs in Modena, Modena L.A. Muratori, Carpi, Sassuolo, Castelvetro di Modena), C.O.F.I.M. SPA & Gianni Gibellini, Franco Appari, Andrea Lucchi, Federica Vagnarelli, Biogas Europa Service & Massimo Faccia, Pierangelo Bertoli Fans Club, Maria Santoro and Valentina Spezzani are strongly acknowledged for their generous support to our research
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