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Experiment Overview

Repository ID: FR-FCM-Z63A Experiment name: Cellular dynamics in the lungs of neonatal and juvenile mice in response to E. coli MIFlowCyt score: 38.00%
Primary researcher: Alan Scott PI/manager: Alan Scott Uploaded by: Alan Scott
Experiment dates: 2023-02-13 - Dataset uploaded: Feb 2023 Last updated: Jun 2023
Keywords: None Manuscripts:
Organizations: None
Purpose: Bacterial pneumonias cause significantly higher morbidity and mortality in neonates compared to other age groups. To understand the immune mechanisms that underlie these age-related differences, we employed a mouse model of E. coli pneumonia to examine cellular and molecular dynamics in immune responsiveness in neonates (PND 3-5) and juveniles (PND 12-18) at 24, 48, and 72 hours.
Conclusion: We found significant differences in the early cellular and molecular dynamics in the lungs that likely contribute to the elevated susceptibility of neonates to bacterial pneumonia and could represent targets for intervention to improve respiratory outcomes and survivability of neonates.
Comments: None
Funding: Not disclosed
Quality control: None
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