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Experiment Overview

Repository ID: FR-FCM-Z5N7 Experiment name: Caerin 1.1 and 1.9 regulate macrophages MIFlowCyt score: 15.00%
Primary researcher: Tianfang Wang PI/manager: Tianfang Wang Uploaded by: Tianfang Wang
Experiment dates: 2021-05-14 - Dataset uploaded: Aug 2022 Last updated: Aug 2022
Keywords: None Manuscripts:
Organizations: None
Purpose: We demonstrate that caerin induced tumour clearance is associated with infiltration of tumors by IL-12 secreting Ly6C+F4/80+ macrophages demonstrating enhanced IFN-? and Stat1 signaling, renders animals resistant to further tumour challenge, and is lost after macrophage depletion. Our results indicate that caerin1.1/1.9 treatment may enhance the efficacy of current immunotherapy modalities.
Conclusion: None
Comments: None
Funding: Not disclosed
Quality control: None
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