Experiment Overview
| Repository ID: | FR-FCM-Z5N7 | Experiment name: | Caerin 1.1 and 1.9 regulate macrophages | MIFlowCyt score: | 15.00% |
| Primary researcher: | Tianfang Wang | PI/manager: | Tianfang Wang | Uploaded by: | Tianfang Wang |
| Experiment dates: | 2021-05-14 - | Dataset uploaded: | Aug 2022 | Last updated: | Aug 2022 |
| Keywords: | None | Manuscripts: | |||
| Organizations: | None | ||||
| Purpose: | We demonstrate that caerin induced tumour clearance is associated with infiltration of tumors by IL-12 secreting Ly6C+F4/80+ macrophages demonstrating enhanced IFN-? and Stat1 signaling, renders animals resistant to further tumour challenge, and is lost after macrophage depletion. Our results indicate that caerin1.1/1.9 treatment may enhance the efficacy of current immunotherapy modalities. | ||||
| Conclusion: | None | ||||
| Comments: | None | ||||
| Funding: | Not disclosed | ||||
| Quality control: | None | ||||
