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Notice: Temporary Suspension of New Experiment Creation
We have temporarily disabled the creation of new experiments as we are continuously running out of space. This issue has been impacting both uploads and downloads from FlowRepository. By taking this step, we aim to make downloads of existing data more reliable.
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Notice: Temporary Shutdown of Flow Repository
This is a notice that Flow Repository will be temporarily down Friday, May 16, 2025 through Sunday, May 18, 2025 due to necessary server room hardware repairs.
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Experiment Overview

Repository ID: FR-FCM-Z267 Experiment name: FlowSOM analysis R688* Roquin-1 PBMCs MIFlowCyt score: 55.50%
Primary researcher: Simon Tavernier PI/manager: Simon Tavernier Uploaded by: Simon Tavernier
Experiment dates: 2019-07-19 - 2019-07-19 Dataset uploaded: Jul 2019 Last updated: Jul 2019
Keywords: None Manuscripts:
Organizations: VIB-Ghent University, Inflammation Research Center, Ghent, (Belgium)
Purpose: Analysis of the immunological alterations in a human case of uncontrolled hyper-inflammation resembling HLH in presence of a novel nonsense R688*/R688* RC3H1 variant.
Conclusion: Expansion of naive B cells with a marked maturation deficit. Expansion of CD4 and CD8 effector T cells. Expansion of Tregs. Expansion of CCR4+CCR6+ CD4 T cells. Reduction in CD56hi NK cells and basophils.
Comments: None
Funding: Not disclosed
Quality control: None


Experiment variables

Individuals
· Healthy controls Full_HC249_F_25_031.fcs · Full_HC255_F_26_032.fcs · Full_HC256_F_30_033.fcs · Full_HC257_F_29_034.fcs · Full_HC258_M_23_035.fcs · Full_HC259_036.fcs · Full_HC262_037.fcs
· R688*/R688* Proband Full_PID630_028.fcs

Sample Type
· PBMCS Full_HC249_F_25_031.fcs · Full_HC255_F_26_032.fcs · Full_HC256_F_30_033.fcs · Full_HC257_F_29_034.fcs · Full_HC258_M_23_035.fcs · Full_HC259_036.fcs · Full_HC262_037.fcs · Full_PID630_028.fcs

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