Experiment Overview
| Repository ID: | FR-FCM-Z267 | Experiment name: | FlowSOM analysis R688* Roquin-1 PBMCs | MIFlowCyt score: | 55.50% |
| Primary researcher: | Simon Tavernier | PI/manager: | Simon Tavernier | Uploaded by: | Simon Tavernier |
| Experiment dates: | 2019-07-19 - 2019-07-19 | Dataset uploaded: | Jul 2019 | Last updated: | Jul 2019 |
| Keywords: | None | Manuscripts: | |||
| Organizations: |
VIB-Ghent University, Inflammation Research Center, Ghent, (Belgium)
|
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| Purpose: | Analysis of the immunological alterations in a human case of uncontrolled hyper-inflammation resembling HLH in presence of a novel nonsense R688*/R688* RC3H1 variant. | ||||
| Conclusion: | Expansion of naive B cells with a marked maturation deficit. Expansion of CD4 and CD8 effector T cells. Expansion of Tregs. Expansion of CCR4+CCR6+ CD4 T cells. Reduction in CD56hi NK cells and basophils. | ||||
| Comments: | None | ||||
| Funding: | Not disclosed | ||||
| Quality control: | None | ||||
Experiment variables
| Individuals | |
|---|---|
| · Healthy controls | Full_HC249_F_25_031.fcs · Full_HC255_F_26_032.fcs · Full_HC256_F_30_033.fcs · Full_HC257_F_29_034.fcs · Full_HC258_M_23_035.fcs · Full_HC259_036.fcs · Full_HC262_037.fcs |
| · R688*/R688* Proband | Full_PID630_028.fcs |
| Sample Type | |
|---|---|
| · PBMCS | Full_HC249_F_25_031.fcs · Full_HC255_F_26_032.fcs · Full_HC256_F_30_033.fcs · Full_HC257_F_29_034.fcs · Full_HC258_M_23_035.fcs · Full_HC259_036.fcs · Full_HC262_037.fcs · Full_PID630_028.fcs |
