Experiment Overview
| Repository ID: | FR-FCM-Z4P5 | Experiment name: | Georg et al. COVID-19 CyTOF data Cohort 1 | MIFlowCyt score: | 26.25% |
| Primary researcher: | Rosario Astaburuaga-García | PI/manager: | Birgit Sawitzki | Uploaded by: | Rosario Astaburuaga-García |
| Experiment dates: | 2020-03-26 - 2021-09-09 | Dataset uploaded: | Dec 2021 | Last updated: | Dec 2021 |
| Keywords: | [Clustering] [Immunophenotyping] [T cell] [CyTOF] [single cell analytics] [COVID-19] | Manuscripts: | |||
| Organizations: |
Charité University Medicine, Berlin, (Germany)
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| Purpose: | To reveal putative immunopathogenic roles of T cells in severe COVID-19, we performed mass cytometry of whole blood samples from mild and severe COVID-19 patients during the acute and convalescent phase, alongside patients with other acute respiratory infections (Flu-like illness, FLI), as well as patients chronically infected by human immunodeficiency virus (HIV) or hepatitis B (HBV) and controls. | ||||
| Conclusion: | We identified highly activated, CD16+ T cells with increased cytotoxic functions in severe COVID-19, which persist during convalescence and maintain their high cytotoxic potential. | ||||
| Comments: | None | ||||
| Funding: | Not disclosed | ||||
| Quality control: | None | ||||
