Experiment Overview
| Repository ID: | FR-FCM-Z4YR | Experiment name: | Detecting treatment effects on intra-tumor immune cell populations using a syngeneic model of murine Nf1-mutant colorectal carcinoma | MIFlowCyt score: | 20.25% |
| Primary researcher: | Sixue Liu | PI/manager: | Sixue Liu | Uploaded by: | Sixue Liu |
| Experiment dates: | 2020-06-01 - | Dataset uploaded: | Jun 2021 | Last updated: | Jul 2024 |
| Keywords: | [priming] [anti-PD-L1] | Manuscripts: | |||
| Organizations: |
UCLA, David Geffen School of Medicine, LOS ANGELES, California (United States)
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| Purpose: | To identify the immune cells in the tumor microenvironment specifically elicited by the regimen of anti-PD-L1 lead-in prior to MEKi combination, we sampled tumors (n=3-4/group) with vehicle or anti-PD-L1 (priming) treatments on day 7 and tumors (n=3-4/group) 3 days and 7 days after treatments in four regimens: (i) MEKi starting day 7, (ii) MEKi+anti-PD-L1 starting day 7, (iii) anti-PD-L1 day0-7, MEKi starting day 7, and (iv) anti-PD-L1 day0-7, anti-PD-L1+MEKi starting day 7. | ||||
| Conclusion: | None | ||||
| Comments: | None | ||||
| Funding: | Not disclosed | ||||
| Quality control: | None | ||||
