Experiment Overview
| Repository ID: | FR-FCM-Z625 | Experiment name: | Studying the heterogeneity of CAR-NK cells and their in vivo evolution after adoptive transfer from Mass cytometry profiling | MIFlowCyt score: | 21.00% |
| Primary researcher: | Katy Rezvani | PI/manager: | Katy Rezvani | Uploaded by: | Katy Rezvani |
| Experiment dates: | 2018-06-30 - 2022-11-30 | Dataset uploaded: | Jan 2023 | Last updated: | Jan 2023 |
| Keywords: | [NK cells] [CAR NK] [integration] | Manuscripts: | |||
| Organizations: | None | ||||
| Purpose: | Chimeric antigen receptor (CAR) engineering of natural killer (NK) cells is promising with early- phase clinical studies showing encouraging responses. However, the transcriptional signatures that control the fate of CAR-NK cells after infusion and factors that influence tumor control remain poorly understood. We performed single-cell mass cytometry to study the heterogeneity of CAR-NK cells and their in vivo evolution after adoptive transfer, from the phase of tumor control to relapse. | ||||
| Conclusion: | None | ||||
| Comments: | None | ||||
| Funding: | Not disclosed | ||||
| Quality control: | None | ||||
