Experiment Overview
| Repository ID: | FR-FCM-Z76D | Experiment name: | Virion-incorporated CD14 enables HIV-1 to bind LPS and initiate TLR4 signaling in immune cells. | MIFlowCyt score: | 46.25% |
| Primary researcher: | Arvin Persaud | PI/manager: | Christina Guzzo | Uploaded by: | Arvin Persaud |
| Experiment dates: | 2023-03-01 - 2024-01-31 | Dataset uploaded: | Jan 2024 | Last updated: | Jan 2024 |
| Keywords: | [monocyte] [inflammation] [LPS] [Flow virometry] [human immunodeficiency virus type 1 (HIV-1)] [virion-incorporated proteins] [calibrated flow virometry] [innate immune] | Manuscripts: | |||
| Organizations: |
University of Toronto (Scarborough) , Cell and Systems Biology; UTSC Biological Sciences, Toronto, Ontario (Canada)
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| Purpose: | Characterizing the incorporation of CD14 onto the HIV-1 surface. | ||||
| Conclusion: | CD14 is present in the HIV-1 envelope and allows virions to bind and shuttle LPS to immune cells for inflammatory signaling. | ||||
| Comments: | None | ||||
| Funding: | CIHR; NSERC | ||||
| Quality control: | None | ||||
