Experiment Overview
| Repository ID: | FR-FCM-Z77Y | Experiment name: | Molecular profiles of CAR-T cells engineered with chimeric cytokine receptors | MIFlowCyt score: | 27.75% |
| Primary researcher: | Yuki Kagoya | PI/manager: | Yuki Kagoya | Uploaded by: | Yuki Kagoya |
| Experiment dates: | 2024-01-12 - | Dataset uploaded: | Feb 2024 | Last updated: | Apr 2024 |
| Keywords: | [T cell memory] [T cell exhaustion] [CD19 CAR-T cells] | Manuscripts: | |||
| Organizations: |
Keio University, School of Medicine, Tokyo, (Japan)
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| Purpose: | This experiment aimed to analyze molcular profiles of CAR-T cells expressing our chimeric cytokine receptors (G6/7R or G6/7R-M452L) compared to control CAR-T cells. | ||||
| Conclusion: | G6/7R and G6/7R-M452L-expressing CAR-T cells showed different molecular profiles compared to control CAR-T cells. | ||||
| Comments: | None | ||||
| Funding: | Not disclosed | ||||
| Quality control: | The samples were analyzed by flow cytometry for a subset of the markers to validate the mass cytometry results. | ||||
