Experiment Overview
| Repository ID: | FR-FCM-Z8BY | Experiment name: | Adoptive transfer (Parkinson;s disease mouse model) Flowcytometry data of the brain infiltrating lymphocytes | MIFlowCyt score: | 65.50% |
| Primary researcher: | Moustafa Nouh Badr Elemeery | PI/manager: | Nathalie Labrecque | Uploaded by: | Moustafa Nouh Badr Elemeery |
| Experiment dates: | 2021-01-21 - 2024-09-05 | Dataset uploaded: | Sep 2024 | Last updated: | Sep 2024 |
| Keywords: | [autoimmunity] [Parkinson] [mitochdria antigen presentation] | Manuscripts: | |||
| Organizations: |
Université de Montréal, Centre de recherche de l'hôpital Maisonneuve-Rosemont (CRHMR), Montréal, Québec (Canada)
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| Purpose: | Screening of Brain-Infiltrating T Cells After Adoptive Transfer in a Parkinson's Disease Animal Model of Mitochondrial Autoimmunity | ||||
| Conclusion: | Mitochondrial antigen-specific CD8+ T cells infiltrate at a higher frequency in the absence of PINK1 protein compared to the negative control of OVA peptide-specific T cells. | ||||
| Comments: | None | ||||
| Funding: | ASAP-000525 | ||||
| Quality control: | cytotoxicity validation for in vivo modeling | Assessment of motor impairment and profiling of peripheral circulating cells in the spleen and blood at an early time point (day 7) and on the day of brain collection | |||
