Experiment Overview

Repository ID: FR-FCM-ZYJN Experiment name: Fitness of 48 TDH3 promoter alleles in YPD MIFlowCyt score: 26.25%
Primary researcher: Fabien Duveau PI/manager: Patricia Wittkopp Uploaded by: Fabien Duveau
Experiment dates: 2016-04-19 - 2016-04-20 Dataset uploaded: May 2018 Last updated: Sep 2018
Keywords: [fitness optimum] [expression noise] [cell proliferation] Manuscripts:
Organizations: University of Michigan, Ann Arbor, MI (USA)
Purpose: Quantifying the effect of changing TDH3 expression level and expression noise on fitness. These competitive fitness data are associated with the expression data collected in experiment FR-FCM-ZY8Y for the same TDH3 promoter alleles.
Conclusion: The relationship between TDH3 expression level and fitness is not linear, since fitness is maximized at intermediate levels of expression. An increase in expression noise is beneficial for cell proliferation when the expression level is far from the optimum, but it is detrimental when the expression level is near the optimum.
Comments: None
Funding: Not disclosed
Quality control: None
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