Experiment Overview
| Repository ID: | FR-FCM-Z8CL | Experiment name: | BIA study - interim analysis | MIFlowCyt score: | 24.00% |
| Primary researcher: | Jeske Van Pamelen | PI/manager: | Jeske Van Pamelen | Uploaded by: | Jeske Van Pamelen |
| Experiment dates: | 2019-01-01 - 2021-12-31 | Dataset uploaded: | Oct 2024 | Last updated: | Oct 2024 |
| Keywords: | [CyTOF] [multiple sclerosis] [cladribine tablets] | Manuscripts: | |||
| Organizations: | None | ||||
| Purpose: | To describe the changes that cladribine tablets effectuate in the immunological profile of patients with relapsing remitting multiple sclerosis, and to determine if the composition of the immunological profile differs between responders and nonresponders. | ||||
| Conclusion: | Three months after treatment we found a significant decline of naïve and transitional B cells and memory B cells, and of CD57+ CD56dim NK cells. Twelve months after treatment the values changed back to baseline levels, except for the memory B cells. No significant differences based on response status were found. | ||||
| Comments: | Sample description contains visit number (baseline, after 3 and 12 months). Additional file 'Related samples' explains which samples are from the same patient. Additional analysis on microbiota in the same population took place. This database can be found via https://doi.org/10.17026/LS/GDHNO0. | ||||
| Funding: | Not disclosed | ||||
| Quality control: | None | ||||
